Abstract:
Small GTPases are small protein switches that cycle between "on" states and "off" states and are key stop or go deciders in many important cellular tasks, such as growth or death. There are many distinct versions of these proteins in cells, each with a specific task or pathway. This project will investigate why proteins that interact with a GTPase in one pathway are specifically paired to their distinct GTPase and do not cross talk with GTPases in other pathways. This is a key unanswered question of major biomedical importance.
UC PI:
John Kuriyan
Department of Molecular and Cellular Biology / Chemistry, UC Berkeley
France PI:
Jacqueline Cherfils
Laboratoire de Biologie et Pharmacologie Appliquée, CNRS / École Normale Supérieure Paris-Saclay
Publication date:
July 1, 2020
Publication type:
Funded Project